Pathology EMQ template.

Name: Samreen Rizvi

Candidate number:

Theme: Plasma Proteins

OPTION LIST

A	Bence Jones Protein	I	Fibrinogen
B	Albumin	J	C3
C	Caeruloplasmin	K	CEA
D	CRP	L	CA125
E	PSA	M	C1-esterase inhibitor
F	Transferrin	N	IgE
J	Alpha-1 antitrypsin	O	Haptoglobin
H	Thyroxine-binding globulin	P	AFP

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. A 32 year old woman, presents to her GP with a 4 month history of increasing dysphagia, mood swings and forgetfulness. Her GP notes a right-sided mass on abdominal examination. Levels of which protein would be most useful in confirming her diagnosis?

2. Which plasma protein is associated with an autosomal dominant condition characterised by clinical features of hereditary angioedema and swelling.

3. A 56 year-old gentleman presents to the surgical outpatients clinic with suspected colorectal carcinoma, which tumour maker would be useful to assess his condition?

4. Levels of this protein are used to detect children at risk of spina bifida and neural tube defects in pregnancy.

5. A 68 year-old woman complaining of lower back pain has a bone marrow biopsy which shows the presence of raised plasma cells. Which urinary protein would be diagnostic for her condition?

ANSWERS

1. C

2. M

3. K

4. P

5. A